薬物有害反応を評価するためのスケールとしてNaranjo有害事象因果関係判定スケールというものがありますが、以下の論文に引用されていたので、抜粋します。日常臨床で大変有用なスケールだと思います。

Development and inter-rater reliability of the Liverpool adverse drug reaction causality assessment tool.

PLoS One. 2011;6(12):e28096. doi: 10.1371/journal.pone.0028096. Epub 2011 Dec 14

http://www.ncbi.nlm.nih.gov/pubmed?term=22194808

 

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237416/table/pone-0028096-t001/

 

                                                                                     はい・いいえ・不明

Q1

Are there previous conclusive reports on this reaction?

この有害事象は副作用としてすでに報告されているか?

+1

0

0

Q2

Did the adverse event appear after the suspected drug was administered?

有害事象は疑われている薬剤服用後に発生したか?

+2

-1

0

Q3

Did the adverse reaction improve when the drug was discontinued or
a specific antagonist was administered?

有害事象は薬剤の中断、あるいは拮抗薬の投与で改善したか?

+1

0

0

Q4

Did the adverse reaction reappear after the drug was readministered?

有害事象は薬剤の再投与で再度発生するか?

+2

-1

0

Q5

Are there alternative causes (other than the drug) that could on their own have caused the reaction?

有害事象を起こすと考えられる他の要因があるか(薬剤以外)

-1

+2

0

Q6

Did the reaction reappear when a placebo was given?

有害事象がプラセボにより引き起こされるか?

-1

+1

0

Q7

Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?

血液中に中毒域濃度で薬剤が検出されるか?

+1

0

0

Q8

Was the reaction more severe when the dose was increased, or less severe when the dose was decreased?

薬剤の投与量増加に伴い有害事象は増加するか?、阿多は投与量減量に伴い、有害事象は減少するか

+1

0

0

Q9

Did the patient have a similar reaction to the same or similar drugs in any previous exposure?

当該患者において、以前に同様の薬剤で同様の症状を起こしたことがあるか?

+1

0

0

Q10

Was the adverse event confirmed by any objective evidence?

有害事象は客観的根拠で確認されているか

+1

0

0

 

9点以上:副作用の可能性が高い

58点:副作用の可能性あり

14点:副作用の可能性は低い

0点:副作用かどうかは疑わしい。